Tetramerization and interdomain flexibility of the replication initiation controller YabA enables simultaneous binding to multiple partners

YabA negatively regulates initiation of DNA replication in low-GC Gram-positive bacteria. The protein exerts its control through interactions with the initiator protein DnaA and the sliding clamp DnaN. Here, we combined X-ray crystallography, X-ray scattering (SAXS), modeling and biophysical approac...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Felicori, Liza, Jameson, Katie H., Roblin, Pierre, Fogg, Mark J., Garcia-Garcia, Transito, Ventroux, Magali, Cherrier, Mickaël V., Bazin, Alexandre, Noirot, Philippe, Wilkinson, Anthony J., Molina, Franck, Terradot, Laurent, Noirot-Gros, Marie-Françoise
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705661/
https://ncbi.nlm.nih.gov/pubmed/26615189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1318
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