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Genome-Wide Estimates of Mutation Rates and Spectrum in Schizosaccharomyces pombe Indicate CpG Sites are Highly Mutagenic Despite the Absence of DNA Methylation

We accumulated mutations for 1952 generations in 79 initially identical, haploid lines of the fission yeast Schizosaccharomyces pombe, and then performed whole-genome sequencing to determine the mutation rates and spectrum. We captured 696 spontaneous mutations across the 79 mutation accumulation (M...

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Bibliografiske detaljer
Udgivet i:G3 (Bethesda)
Main Authors: Behringer, Megan G., Hall, David W.
Format: Artigo
Sprog:Inglês
Udgivet: Genetics Society of America 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704713/
https://ncbi.nlm.nih.gov/pubmed/26564949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.115.022129
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