An Amphipathic Undecapeptide with All d-Amino Acids Shows Promising Activity against Colistin-Resistant Strains of Acinetobacter baumannii and a Dual Mode of Action

Multiple strains of Acinetobacter baumannii have developed multidrug resistance (MDR), leaving colistin as the only effective treatment. The cecropin-α–melittin hybrid BP100 (KKLFKKILKYL-NH(2)) and its analogs have previously shown activity against a wide array of plant and human pathogens. In this...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Oddo, Alberto, Thomsen, Thomas T., Kjelstrup, Susanne, Gorey, Ciara, Franzyk, Henrik, Frimodt-Møller, Niels, Løbner-Olesen, Anders, Hansen, Paul R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Clinical Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4704207/
https://ncbi.nlm.nih.gov/pubmed/26574005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01966-15
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