Functional inhibition of urea transporter UT-B enhances endothelial-dependent vasodilatation and lowers blood pressure via L-arginine-endothelial nitric oxide synthase-nitric oxide pathway

Mammalian urea transporters (UTs), UT-A and UT-B, are best known for their role in urine concentration. UT-B is especially distributed in multiple extrarenal tissues with abundant expression in vascular endothelium, but little is known about its role in vascular function. The present study investiga...

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Published in:Sci Rep
Main Authors: Sun, Yi, Lau, Chi-Wai, Jia, Yingli, Li, Yingjie, Wang, Weiling, Ran, Jianhua, Li, Fei, Huang, Yu, Zhou, Hong, Yang, Baoxue
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703984/
https://ncbi.nlm.nih.gov/pubmed/26739766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18697
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