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Rational engineering of a mesohalophilic carbonic anhydrase to an extreme halotolerant biocatalyst
Enzymes expressed by highly salt-tolerant organisms show many modifications compared with salt-affected counterparts including biased amino acid and lower α-helix content, lower solvent accessibility and negative surface charge. Here, we show that halotolerance can be generated in an enzyme solely b...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4703901/ https://ncbi.nlm.nih.gov/pubmed/26687908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10278 |
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