Inhibition of inflammasome activation by Coxiella burnetii type IV secretion system effector IcaA

Coxiella burnetii is a highly infectious bacterium that promotes its own replication in macrophages by inhibiting several host cell responses. Here, we show that C. burnetii inhibits caspase-1 activation in primary mouse macrophages. By using co-infection experiments, we determine that the infection...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Cunha, Larissa D., Ribeiro, Juliana M., Fernandes, Talita D., Massis, Liliana M., Khoo, Chen Ai, Moffatt, Jennifer H., Newton, Hayley J., Roy, Craig R., Zamboni, Dario S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703858/
https://ncbi.nlm.nih.gov/pubmed/26687278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10205
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