An Expanded Analysis of Pharmacogenetics Determinants of Efavirenz Response that Includes 3′-UTR Single Nucleotide Polymorphisms among Black South African HIV/AIDS Patients

Introduction: Efavirenz (EFV) is a non-nucleoside reverse transcriptase inhibitor prescribed as part of first-line highly active antiretroviral therapy (HAART) in South Africa. Despite administration of fixed doses of EFV, inter-individual variability in plasma concentrations has been reported. Poor...

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Detalles Bibliográficos
Publicado en:Front Genet
Main Authors: Swart, Marelize, Evans, Jonathan, Skelton, Michelle, Castel, Sandra, Wiesner, Lubbe, Smith, Peter J., Dandara, Collet
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2016
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703773/
https://ncbi.nlm.nih.gov/pubmed/26779253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2015.00356
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