Integrating Murine and Clinical Trials with Cabozantinib to Understand Roles of MET and VEGFR-2 as Targets for Growth Inhibition of Prostate Cancer

PURPOSE: We performed parallel investigations in cabozantinib-treated patients in a Phase 2 trial and simultaneously in Patient-derived Xenograft (PDX) models to better understand the roles of MET and VEGFR-2 as targets for prostate cancer therapy. EXPERIMENTAL DESIGN: In the clinical trial, radiogr...

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Publicat a:Clin Cancer Res
Autors principals: Varkaris, Andreas, Corn, Paul G., Parikh, Nila U., Efstathiou, Eleni, Song, Jian H., Lee, Yu-Chen, Aparicio, Ana, Hoang, Anh G., Gaur, Sanchaika, Thorpe, Lynnelle, Maity, Sankar N., Eli, Menashe Bar, Czerniak, Bogdan A., Shao, Yiping, Alauddin, Mian, Lin, Sue-Hwa, Logothetis, Christopher J., Gallick, Gary E.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703437/
https://ncbi.nlm.nih.gov/pubmed/26272062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0235
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