Fas-activated mitochondrial apoptosis culls stalled embryonic stem cells to promote differentiation

The intrinsic (mitochondrial) apoptotic pathway is a conserved cell death program crucial for eliminating superfluous, damaged, or incorrectly specified cells [1], and the multi-domain pro-death BCL-2 family proteins BAX and BAK are required for its activation [2, 3]. In response to internal damage...

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Detalhes bibliográficos
Publicado no:Curr Biol
Main Authors: Wang, Eric S., Reyes, Nichole A., Melton, Collin, Huskey, Noelle E., Momcilovic, Olga, Goga, Andrei, Blelloch, Robert, Oakes, Scott A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703423/
https://ncbi.nlm.nih.gov/pubmed/26585277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2015.10.020
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