Injured sensory neuron-derived CSF1 induces microglia proliferation and DAP12-dependent pain

Although microglia are implicated in nerve injury-induced neuropathic pain, how injured sensory neurons engage microglia is unclear. Here we demonstrate that peripheral nerve injury induces de novo expression of colony-stimulating factor 1 (CSF1) in injured sensory neurons. The CSF1 is transported t...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Guan, Zhonghui, Kuhn, Julia A., Wang, Xidao, Colquitt, Bradley, Solorzano, Carlos, Vaman, Smitha, Guan, Andrew K., Evans-Reinsch, Zoe, Braz, Joao, Devor, Marshall, Abboud-Werner, Sherry L., Lanier, Lewis L., Lomvardas, Stavros, Basbaum, Allan I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703328/
https://ncbi.nlm.nih.gov/pubmed/26642091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4189
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