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Hepatitis C Virus NS4B Can Suppress STING Accumulation To Evade Innate Immune Responses
The cyclic dinucleotide 2′,3′-cGAMP can bind the adaptor protein STING (stimulator of interferon [IFN] genes) to activate the production of type I IFNs and proinflammatory cytokines. We found that cGAMP added to the culture medium could suppress the replication of the hepatitis C virus (HCV) genotyp...
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| Publicado no: | J Virol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4702547/ https://ncbi.nlm.nih.gov/pubmed/26468527 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01720-15 |
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