Overexpression of major CDKN3 transcripts is associated with poor survival in lung adenocarcinoma

BACKGROUND: The cyclin-dependent kinase inhibitor 3 (CDKN3) has been perceived as a tumour suppressor. Paradoxically, CDKN3 is often overexpressed in human cancer. It was unclear if CDKN3 overexpression is linked to alternative splicing variants or mutations that produce dominant-negative CDKN3. MET...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Fan, Chao, Chen, Lu, Huang, Qingling, Shen, Tao, Welsh, Eric A, Teer, Jamie K, Cai, Jianfeng, Cress, W Douglas, Wu, Jie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Genetics & Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701993/
https://ncbi.nlm.nih.gov/pubmed/26554648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.378
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