Overexpression of major CDKN3 transcripts is associated with poor survival in lung adenocarcinoma

BACKGROUND: The cyclin-dependent kinase inhibitor 3 (CDKN3) has been perceived as a tumour suppressor. Paradoxically, CDKN3 is often overexpressed in human cancer. It was unclear if CDKN3 overexpression is linked to alternative splicing variants or mutations that produce dominant-negative CDKN3. MET...

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Bibliografische gegevens
Gepubliceerd in:Br J Cancer
Hoofdauteurs: Fan, Chao, Chen, Lu, Huang, Qingling, Shen, Tao, Welsh, Eric A, Teer, Jamie K, Cai, Jianfeng, Cress, W Douglas, Wu, Jie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2015
Onderwerpen:
Genetics & Genomics
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701993/
https://ncbi.nlm.nih.gov/pubmed/26554648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.378
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