Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome

Increasing evidence implicates abnormal Ras signaling as a major contributor in neurodevelopmental disorders, yet how such signaling causes cortical pathogenesis is unknown. We examined the consequences of aberrant Ras signaling in the developing mouse brain and uncovered several critical phenotypes...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Rooney, Gemma E., Goodwin, Alice F., Depeille, Philippe, Sharir, Amnon, Schofield, Claude M., Yeh, Erika, Roose, Jeroen P., Klein, Ophir D., Rauen, Katherine A., Weiss, Lauren A., Ullian, Erik M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701956/
https://ncbi.nlm.nih.gov/pubmed/26740656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1547-15.2016
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