Aldosterone Induces Renal Fibrosis and Inflammatory M1-Macrophage Subtype via Mineralocorticoid Receptor in Rats

We aimed to evaluate macrophages heterogeneity and structural, functional and inflammatory alterations in rat kidney by aldosterone + salt administration. The effects of treatment with spironolactone on above parameters were also analyzed. Male Wistar rats received aldosterone (1 mgkg(-1)d(-1)) + 1%...

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I publikationen:PLoS One
Huvudupphovsmän: Martín-Fernández, Beatriz, Rubio-Navarro, Alfonso, Cortegano, Isabel, Ballesteros, Sandra, Alía, Mario, Cannata-Ortiz, Pablo, Olivares-Álvaro, Elena, Egido, Jesús, de Andrés, Belén, Gaspar, María Luisa, de las Heras, Natalia, Lahera, Vicente, Moreno, Juan Antonio
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2016
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701403/
https://ncbi.nlm.nih.gov/pubmed/26730742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145946
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