Aspirin and atenolol enhance metformin activity against breast cancer by targeting both neoplastic and microenvironment cells

Metformin can induce breast cancer (BC) cell apoptosis and reduce BC local and metastatic growth in preclinical models. Since Metformin is frequently used along with Aspirin or beta-blockers, we investigated the effect of Metformin, Aspirin and the beta-blocker Atenolol in several BC models. In vitr...

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Udgivet i:Sci Rep
Main Authors: Talarico, Giovanna, Orecchioni, Stefania, Dallaglio, Katiuscia, Reggiani, Francesca, Mancuso, Patrizia, Calleri, Angelica, Gregato, Giuliana, Labanca, Valentina, Rossi, Teresa, Noonan, Douglas M., Albini, Adriana, Bertolini, Francesco
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700497/
https://ncbi.nlm.nih.gov/pubmed/26728433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18673
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