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Topographic confinement of epithelial clusters induces epithelial-to-mesenchymal transition in compliant matrices

Epithelial cells disengage from their clusters and become motile by undergoing epithelial-to-mesenchymal transition (EMT), an essential process for both embryonic development and tumor metastasis. Growing evidence suggests that high extracellular matrix (ECM) stiffness induces EMT. In reality, epith...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Nasrollahi, Samila, Pathak, Amit
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700414/
https://ncbi.nlm.nih.gov/pubmed/26728047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18831
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