Papillomavirus-Associated Tumor Formation Critically Depends on c-Fos Expression Induced by Viral Protein E2 and Bromodomain Protein Brd4

We investigated the mechanism of how the papillomavirus E2 transcription factor can activate promoters through activator protein (AP)1 binding sites. Using an unbiased approach with an inducible cell line expressing the viral transcription factor E2 and transcriptome analysis, we found that E2 induc...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Delcuratolo, Maria, Fertey, Jasmin, Schneider, Markus, Schuetz, Johanna, Leiprecht, Natalie, Hudjetz, Benjamin, Brodbeck, Stephan, Corall, Silke, Dreer, Marcel, Schwab, Roxana Michaela, Grimm, Martin, Wu, Shwu-Yuan, Stubenrauch, Frank, Chiang, Cheng-Ming, Iftner, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699637/
https://ncbi.nlm.nih.gov/pubmed/26727473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005366
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