Transcriptome analysis in calorie-restricted rats implicates epigenetic and post-translational mechanisms in neuroprotection and aging

BACKGROUND: Caloric restriction (CR) can increase longevity in rodents and improve memory function in humans. α-Lipoic acid (LA) has been shown to improve memory function in rats, but not longevity. While studies have looked at survival in rodents after switching from one diet to another, the underl...

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Vydáno v:Genome Biol
Hlavní autoři: Wood, Shona H., van Dam, Sipko, Craig, Thomas, Tacutu, Robi, O’Toole, Amy, Merry, Brian J., de Magalhães, João Pedro
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699360/
https://ncbi.nlm.nih.gov/pubmed/26694192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0847-2
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