Hydrogel-Forming Microneedle Arrays Allow Detection of Drugs and Glucose In Vivo: Potential for Use in Diagnosis and Therapeutic Drug Monitoring

We describe, for the first time the use of hydrogel-forming microneedle (MN) arrays for minimally-invasive extraction and quantification of drug substances and glucose from skin in vitro and in vivo. MN prepared from aqueous blends of hydrolysed poly(methyl-vinylether-co-maleic anhydride) (11.1% w/w...

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Bibliographic Details
Published in:PLoS One
Main Authors: Caffarel-Salvador, Ester, Brady, Aaron J., Eltayib, Eyman, Meng, Teng, Alonso-Vicente, Ana, Gonzalez-Vazquez, Patricia, Torrisi, Barbara M., Vicente-Perez, Eva Maria, Mooney, Karen, Jones, David S., Bell, Steven E. J., McCoy, Colin P., McCarthy, Helen O., McElnay, James C., Donnelly, Ryan F.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699208/
https://ncbi.nlm.nih.gov/pubmed/26717198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145644
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