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Glypican-3 is a prognostic factor and an immunotherapeutic target in hepatocellular carcinoma

Glypican-3 (GPC3) is a cell surface oncofetal proteoglycan that is anchored by glycosylphosphatidylinositol. Whereas GPC3 is abundant in fetal liver, its expression is hardly detectable in adult liver. Importantly, GPC3 is overexpressed in hepatocellular carcinoma (HCC), and several immunohistochemi...

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Detalhes bibliográficos
Publicado no:World J Gastroenterol
Main Authors: Haruyama, Yukihiro, Kataoka, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Inc 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4698492/
https://ncbi.nlm.nih.gov/pubmed/26755876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v22.i1.275
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