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F-actin clustering and cell dysmotility induced by the pathological W148R missense mutation of filamin B at the actin-binding domain
Filamin B (FLNB) is a dimeric actin-binding protein that orchestrates the reorganization of the actin cytoskeleton. Congenital mutations of FLNB at the actin-binding domain (ABD) are known to cause abnormalities of skeletal development, such as atelosteogenesis types I and III and Larsen's synd...
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| Udgivet i: | Am J Physiol Cell Physiol |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4698447/ https://ncbi.nlm.nih.gov/pubmed/26491051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00274.2015 |
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