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Carvedilol binding to β(2)-adrenergic receptors inhibits CFTR-dependent anion secretion in airway epithelial cells
Carvedilol functions as a nonselective β-adrenergic receptor (AR)/α(1)-AR antagonist that is used for treatment of hypertension and heart failure. Carvedilol has been shown to function as an inverse agonist, inhibiting G protein activation while stimulating β-arrestin-dependent signaling and inducin...
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| Publicado no: | Am J Physiol Lung Cell Mol Physiol |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4698435/ https://ncbi.nlm.nih.gov/pubmed/26566905 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00296.2015 |
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