Aberrant DNA Methylation Is Associated with a Poor Outcome in Juvenile Myelomonocytic Leukemia

Juvenile myelomonocytic leukemia (JMML), an overlap of myelodysplastic / myeloproliferative neoplasm, is an intractable pediatric myeloid neoplasm. Epigenetic regulation of transcription, particularly by CpG methylation, plays an important role in tumor progression, mainly by repressing tumor-suppre...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sakaguchi, Hirotoshi, Muramatsu, Hideki, Okuno, Yusuke, Makishima, Hideki, Xu, Yinyan, Furukawa-Hibi, Yoko, Wang, Xinan, Narita, Atsushi, Yoshida, Kenichi, Shiraishi, Yuichi, Doisaki, Sayoko, Yoshida, Nao, Hama, Asahito, Takahashi, Yoshiyuki, Yamada, Kiyofumi, Miyano, Satoru, Ogawa, Seishi, Maciejewski, Jaroslaw P., Kojima, Seiji
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697810/
https://ncbi.nlm.nih.gov/pubmed/26720758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145394
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