Molecular Mechanism Responsible for Fibronectin-controlled Alterations in Matrix Stiffness in Advanced Chronic Liver Fibrogenesis

Fibrosis is characterized by extracellular matrix (ECM) remodeling and stiffening. However, the functional contribution of tissue stiffening to noncancer pathogenesis remains largely unknown. Fibronectin (Fn) is an ECM glycoprotein substantially expressed during tissue repair. Here we show in advanc...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Iwasaki, Ayumi, Sakai, Keiko, Moriya, Kei, Sasaki, Takako, Keene, Douglas R., Akhtar, Riaz, Miyazono, Takayoshi, Yasumura, Satoshi, Watanabe, Masatoshi, Morishita, Shin, Sakai, Takao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697189/
https://ncbi.nlm.nih.gov/pubmed/26553870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.691519
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