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Proximal Roux-en-Y Gastric Bypass Alters Drug Absorption Pattern But Not Systemic Exposure of CYP3A4 and P-glycoprotein Substrates
STUDY OBJECTIVES: To evaluate the effect of Roux-en-Y gastric bypass surgery (RYGB) on the pharmacokinetics of midazolam (a CYP3A4 substrate) and digoxin (a P-glycoprotein substrate). DESIGN: Prospective, nonblinded, longitudinal, single-dose pharmacokinetic study in three phases: presurgery baselin...
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| Publicado no: | Pharmacotherapy |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4696861/ https://ncbi.nlm.nih.gov/pubmed/25757445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/phar.1560 |
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