Screen-based identification and validation of four new ion channels as regulators of renal ciliogenesis

To investigate the contribution of ion channels to ciliogenesis, we carried out a small interfering RNA (siRNA)-based reverse genetics screen of all ion channels in the mouse genome in murine inner medullary collecting duct kidney cells. This screen revealed four candidate ion channel genes: Kcnq1,...

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Udgivet i:J Cell Sci
Main Authors: Slaats, Gisela G., Wheway, Gabrielle, Foletto, Veronica, Szymanska, Katarzyna, van Balkom, Bas W. M., Logister, Ive, Den Ouden, Krista, Keijzer-Veen, Mandy G., Lilien, Marc R., Knoers, Nine V., Johnson, Colin A., Giles, Rachel H.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4696498/
https://ncbi.nlm.nih.gov/pubmed/26546361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.176065
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