p53-Dependent Senescence in Mesenchymal Stem Cells under Chronic Normoxia Is Potentiated by Low-Dose γ-Irradiation

Mesenchymal stem cells (MSCs) are a source of adult multipotent cells important in tissue regeneration. Murine MSCs are known to proliferate poorly in vitro under normoxia. The aim of this study is to analyze the interaction of nonphysiological high oxygen and low-dose γ-irradiation onto growth, sen...

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Detalhes bibliográficos
Publicado no:Stem Cells Int
Main Authors: Höfig, Ines, Ingawale, Yashodhara, Atkinson, Michael J., Hertlein, Heidi, Nelson, Peter J., Rosemann, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695678/
https://ncbi.nlm.nih.gov/pubmed/26788069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/6429853
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