Endogenous secreted phospholipase A(2) group X regulates cysteinyl leukotrienes sy nthesis by human eosinophils

BACKGROUND: Phospholipase A(2)s mediate the rate-limiting step in the formation of eicosanoids such as cysteinyl leukotrienes (CysLT). Group IVA cytosolic PLA(2) (cPLA(2)α) is thought to be the dominant PLA(2) in eosinophils; however, eosinophils also have secreted PLA(2) (sPLA(2)) activity that has...

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: Hallstrand, Teal S., Lai, Ying, Hooper, Kathryn A, Oslund, Rob C., Altemeier, William A., Matute-Bello, Gustavo, Gelb, Michael H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695325/
https://ncbi.nlm.nih.gov/pubmed/26139511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.05.026
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