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A Small n Sequential Multiple Assignment Randomized Trial Design For Use in Rare Disease Research

BACKGROUND: Clinical trials in rare diseases are difficult to conduct due to the limited number of patients available with each disorder. We developed a Phase 2 trial which is a small n sequential multiple assignment randomized trial (snSMART) design to test several treatments for a rare disease for...

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Detalhes bibliográficos
Publicado no:Contemp Clin Trials
Main Authors: Tamura, Roy N., Krischer, Jeffrey P., Pagnoux, Christian, Micheletti, Robert, Grayson, Peter C., Chen, Yeh-Fong, Merkel, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695231/
https://ncbi.nlm.nih.gov/pubmed/26586608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cct.2015.11.010
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