Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis

Concentrations of circulating galectin-3, a metastasis promoter, are greatly increased in cancer patients. Here we show that 2- or 6-de-O-sulfated, N-acetylated heparin derivatives are galectin-3 binding inhibitors. These chemically modified heparin derivatives inhibited galectin-3-ligand binding an...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Duckworth, Carrie A., Guimond, Scott E., Sindrewicz, Paulina, Hughes, Ashley J., French, Neil S., Lian, Lu-Yun, Yates, Edwin A., Pritchard, D. Mark, Rhodes, Jonathan M., Turnbull, Jeremy E., Yu, Lu-Gang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695144/
https://ncbi.nlm.nih.gov/pubmed/26160844
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