Trypsinogen 4 boosts tumor endothelial cells migration through proteolysis of tissue factor pathway inhibitor-2

Proteasescontribute to cancer in many ways, including tumor vascularization and metastasis, and their pharmacological inhibition is a potential anticancer strategy. We report that human endothelial cells (EC) express the trypsinogen 4 isoform of the serine protease 3 (PRSS3), and lack both PRSS2 and...

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發表在:Oncotarget
Main Authors: Ghilardi, Carmen, Silini, Antonietta, Figini, Sara, Anastasia, Alessia, Lupi, Monica, Fruscio, Robert, Giavazzi, Raffaella, Bani, MariaRosa
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2015
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Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695067/
https://ncbi.nlm.nih.gov/pubmed/26318044
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