Fisetin, a phytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cells

Melanoma is the most deadly form of cutaneous malignancy, and its incidence rates are rising worldwide. In melanoma, constitutive activation of the BRAF/MEK/ERK (MAPK) and PI3K/AKT/mTOR (PI3K) signaling pathways plays a pivotal role in cell proliferation, survival and tumorigenesis. A combination of...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Pal, Harish Chandra, Baxter, Ronald D., Hunt, Katherine M., Agarwal, Jyoti, Elmets, Craig A., Athar, Mohammad, Afaq, Farrukh
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695061/
https://ncbi.nlm.nih.gov/pubmed/26299806
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