Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1

Investigating existing drugs for repositioning can enable overcoming bottlenecks in the drug development process. Here, we investigated the effect and molecular mechanism of the antipsychotic drug chlorpromazine (CPZ) and identified its potential for treating colorectal cancer (CRC). Human CRC cell...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lee, Wen-Ying, Lee, Wai-Theng, Cheng, Chia-Hsiung, Chen, Ku-Chung, Chou, Chih-Ming, Chung, Chu-Hung, Sun, Min-Siou, Cheng, Hung-Wei, Ho, Meng-Ni, Lin, Cheng-Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695010/
https://ncbi.nlm.nih.gov/pubmed/26363315
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