Reciprocal regulation between sirtuin-1 and angiotensin-II in the substantia nigra: implications for aging and neurodegeneration

Local angiotensin II (AII) and sirtuin 1 (SIRT1) play a major role in the modulation of neuroinflammation, oxidative stress and aging-related dopaminergic vulnerability to damage. However, it is not known whether the modulation is related to reciprocal regulation between SIRT1 and AII. In the presen...

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Udgivet i:Oncotarget
Main Authors: Diaz-Ruiz, Carmen, Rodriguez-Perez, Ana I., Beiroa, Daniel, Rodriguez-Pallares, Jannette, Labandeira-Garcia, Jose L.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper: Gerotarget (Focus on Aging)
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694944/
https://ncbi.nlm.nih.gov/pubmed/26384348
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