Plasminogen Activator Inhibitor-1 Controls Vascular Integrity by Regulating VE-Cadherin Trafficking

BACKGROUND: Plasminogen activator inhibitor-1 (PAI-1), a serine protease inhibitor, is expressed and secreted by endothelial cells. Patients with PAI-1 deficiency show a mild to moderate bleeding diathesis, which has been exclusively ascribed to the function of PAI-1 in down-regulating fibrinolysis....

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Daniel, Anna E., Timmerman, Ilse, Kovacevic, Igor, Hordijk, Peter L., Adriaanse, Luc, Paatero, Ilkka, Belting, Heinz-Georg, van Buul, Jaap D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694698/
https://ncbi.nlm.nih.gov/pubmed/26714278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145684
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