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Effect of diphenoxylate on CYP450 isoforms activity in rats

In order to investigate the effects of diphenoxylate on the metabolic capacity of cytochrome P450 (CYP) enzymes, a cocktail method was employed to evaluate the activities of CYP2B6, CYP2D6, CYP2C19, CYP1A2, CYP3A4, CYP2C9. The rats were randomly divided into diphenoxylate group (Low, Medium, High) a...

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Detalhes bibliográficos
Publicado no:Int J Clin Exp Med
Main Authors: Geng, Peiwu, Cai, Jinzhang, Wang, Shuanghu, Yang, Suping, Liu, Zezheng, Lin, Yingying, Wen, Congcong, Wang, Xianqin, Zhou, Yunfang, Zhang, Meiling
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694398/
https://ncbi.nlm.nih.gov/pubmed/26770498
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