Loss of IL‐4Rα–mediated PI3K signaling accelerates the progression of IgE/mast cell–mediated reactions

Clinical and experimental evidence indicate that polymorphisms within the interleukin 4 (IL‐4) receptor (IL‐4R) chain are sufficient for altered strength of IL‐4/IL‐13 signaling, leading to an exaggerated allergic inflammatory response and increase susceptibility to allergic phenotypes. In the prese...

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Bibliographische Detailangaben
Veröffentlicht in:Immun Inflamm Dis
Hauptverfasser: Sledd, Jane, Wu, David, Ahrens, Richard, Lee, Jeebong, Waggoner, Lisa, Tsai, Ying Ting, Wang, Yui‐Hsi, Hogan, Simon P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2015
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4693723/
https://ncbi.nlm.nih.gov/pubmed/26734464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/iid3.80
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