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A pharmacokinetic–pharmacodynamic model for intrathecal baclofen in patients with severe spasticity
AIMS: Intrathecal baclofen (ITB) has proven to be an effective and safe treatment for severe spasticity. However, although ITB is used extensively, clinical decisions are based on very scarce pharmacokinetic–pharmacodynamic (PKPD) data. The aim of this study was to measure baclofen CSF concentration...
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| Udgivet i: | Br J Clin Pharmacol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4693571/ https://ncbi.nlm.nih.gov/pubmed/27099877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12781 |
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