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A pharmacokinetic–pharmacodynamic model for intrathecal baclofen in patients with severe spasticity

AIMS: Intrathecal baclofen (ITB) has proven to be an effective and safe treatment for severe spasticity. However, although ITB is used extensively, clinical decisions are based on very scarce pharmacokinetic–pharmacodynamic (PKPD) data. The aim of this study was to measure baclofen CSF concentration...

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Bibliografske podrobnosti
izdano v:Br J Clin Pharmacol
Main Authors: Heetla, H. W., Proost, J. H., Molmans, B. H., Staal, M. J., van Laar, T.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4693571/
https://ncbi.nlm.nih.gov/pubmed/27099877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12781
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