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Olaparib
Olaparib is used to treat BReast CAncer susceptibility protein (BRCA)‐associated, platinum‐sensitive ovarian cancer. Olaparib inhibits poly(ADP‐ribose) polymerase, thereby blocking the repair of single‐strand DNA breaks. This results in synthetic lethality in BRCA‐associated cancer cells, which have...
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| Publicado en: | Br J Clin Pharmacol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4693566/ https://ncbi.nlm.nih.gov/pubmed/26344419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12761 |
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