Cholesterol‐loaded nanoparticles ameliorate synaptic and cognitive function in Huntington's disease mice

Brain cholesterol biosynthesis and cholesterol levels are reduced in mouse models of Huntington's disease (HD), suggesting that locally synthesized, newly formed cholesterol is less available to neurons. This may be detrimental for neuronal function, especially given that locally synthesized ch...

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Bibliografiska uppgifter
I publikationen:EMBO Mol Med
Huvudupphovsmän: Valenza, Marta, Chen, Jane Y, Di Paolo, Eleonora, Ruozi, Barbara, Belletti, Daniela, Ferrari Bardile, Costanza, Leoni, Valerio, Caccia, Claudio, Brilli, Elisa, Di Donato, Stefano, Boido, Marina M, Vercelli, Alessandro, Vandelli, Maria A, Forni, Flavio, Cepeda, Carlos, Levine, Michael S, Tosi, Giovanni, Cattaneo, Elena
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2015
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4693506/
https://ncbi.nlm.nih.gov/pubmed/26589247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201505413
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