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RNase P-Mediated Sequence-Specific Cleavage of RNA by Engineered External Guide Sequences

The RNA cleavage activity of RNase P can be employed to decrease the levels of specific RNAs and to study their function or even to eradicate pathogens. Two different technologies have been developed to use RNase P as a tool for RNA knockdown. In one of these, an external guide sequence, which mimic...

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: Derksen, Merel, Mertens, Vicky, Pruijn, Ger J.M.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4693268/
https://ncbi.nlm.nih.gov/pubmed/26569326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom5043029
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