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Dormant Intestinal Stem Cells are Regulated by PTEN and Nutritional Status
The cellular and molecular mechanisms underlying adaptive changes to physiological stress within the intestinal epithelium remain poorly understood. Here, we show that PTEN, a negative regulator of the PI3K→AKT→mTORC1 signaling pathway, is an important regulator of dormant intestinal stem cells (dIS...
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Pubblicato in: | Cell Rep |
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Autori principali: | , , , , , , , , , , , , |
Natura: | Artigo |
Lingua: | Inglês |
Pubblicazione: |
2015
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Soggetti: | |
Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4691543/ https://ncbi.nlm.nih.gov/pubmed/26686631 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.11.035 |
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