Dormant Intestinal Stem Cells are Regulated by PTEN and Nutritional Status

The cellular and molecular mechanisms underlying adaptive changes to physiological stress within the intestinal epithelium remain poorly understood. Here, we show that PTEN, a negative regulator of the PI3K→AKT→mTORC1 signaling pathway, is an important regulator of dormant intestinal stem cells (dIS...

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Publicado en:Cell Rep
Autores principales: Richmond, Camilla A., Shah, Manasvi S., Deary, Luke T., Trotier, Danny C., Thomas, Horatio, Ambruzs, Dana M., Jiang, Lijie, Whiles, Bristol B., Rickner, Hannah D., Montgomery, Robert K., Tovaglieri, Alessio, Carlone, Diana L., Breault, David T.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691543/
https://ncbi.nlm.nih.gov/pubmed/26686631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.11.035
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