Activation of ULK Kinase and Autophagy by GABARAP Trafficking from the Centrosome Is Regulated by WAC and GM130

Starvation-induced autophagy requires activation of the ULK complex at the phagophore. Two Golgi proteins, WAC and GM130, regulate autophagy, however their mechanism of regulation is unknown. In search of novel interaction partners of WAC, we found that GM130 directly interacts with WAC, and this in...

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Publicado no:Mol Cell
Main Authors: Joachim, Justin, Jefferies, Harold B.J., Razi, Minoo, Frith, David, Snijders, Ambrosius P., Chakravarty, Probir, Judith, Delphine, Tooze, Sharon A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691241/
https://ncbi.nlm.nih.gov/pubmed/26687599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.11.018
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