Hypoxia and TGF-β1 lead to endostatin resistance by cooperatively increasing cancer stem cells in A549 transplantation tumors

BACKGROUND: Lung cancer is the leading cause of cancer-related deaths worldwide, and treatments for lung cancer have a high failure rate. Anti-angiogenic therapy is also often ineffective because of refractory disease. Endostatin (ES) is one of the most widely-used anti-angiogenic drugs for lung can...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Biosci
Hauptverfasser: Wang, Yuyi, Jiang, Ming, Li, Zhixi, Wang, Jiantao, Du, Chi, Yanyang, Liu, Yu, Yang, Wang, Xia, Zhang, Nan, Zhao, Maoyuan, Wang, Li, Li, Mei, Luo, Feng
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4690275/
https://ncbi.nlm.nih.gov/pubmed/26705466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-015-0064-4
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