Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger

Human L3MBTL1, which contains three malignant brain tumor (MBT) repeats, binds monomethylated and dimethylated lysines, but not trimethylated lysines, in several histone sequence contexts. In crystal structures of L3MBTL1 complexes, the monomethyl- and dimethyllysines insert into a narrow and deep c...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Li, Haitao, Fischle, Wolfgang, Wang, Wooikoon, Duncan, Elizabeth M., Liang, Lena, Murakami-Ishibe, Satoko, Allis, C. David, Patel, Dinshaw J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689580/
https://ncbi.nlm.nih.gov/pubmed/18042461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.10.023
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