Elimination of Chromosomal Island SpyCIM1 from Streptococcus pyogenes Strain SF370 Reverses the Mutator Phenotype and Alters Global Transcription

Streptococcus pyogenes chromosomal island M1 (SpyCIM1) integrates by site-specific recombination into the 5’ end of DNA mismatch repair (MMR) gene mutL in strain SF370SmR, blocking transcription of it and the downstream operon genes. During exponential growth, SpyCIM1 excises from the chromosome and...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Hendrickson, Christina, Euler, Chad W., Nguyen, Scott V., Rahman, Maliha, McCullor, Kimberly A., King, Catherine J., Fischetti, Vincent A., McShan, W. Michael
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4689407/
https://ncbi.nlm.nih.gov/pubmed/26701803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145884
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