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Two nonpeptide tachykinin antagonists act through epitopes on corresponding segments of the NK1 and NK2 receptors.

The molecular mechanism of action for two chemically distinct and highly selective, nonpeptide antagonists, CP-96,345 and SR-48,968, was studied by development of a series of chimeric constructs between their respective target receptors, the NK1 (substance P) and NK2 (neurokinin A) receptors. The bi...

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Detalhes bibliográficos
Main Authors: Gether, U, Yokota, Y, Emonds-Alt, X, Brelière, J C, Lowe, J A, Snider, R M, Nakanishi, S, Schwartz, T W
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC46894/
https://ncbi.nlm.nih.gov/pubmed/7687062
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