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The Solution Structure of a Nonribosomal Peptide Synthetase Carrier Protein Loaded with its Substrate Reveals Transient, Well-defined Contacts
Nonribosomal peptide synthetases (NRPSs) are microbial enzymes that produce a wealth of important natural products by condensing substrates in an assembly line manner. The proper sequence of substrates is obtained by tethering them to phosphopantetheinyl arms of holo carrier proteins (CPs) via a thi...
Shranjeno v:
| izdano v: | J Am Chem Soc |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4689197/ https://ncbi.nlm.nih.gov/pubmed/26334259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b07772 |
| Oznake: |
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