Combining Optical Reporter Proteins with Different Half-lives to Detect Temporal Evolution of Hypoxia and Reoxygenation in Tumors

Here we have developed a hypoxia response element driven imaging strategy that combined the hypoxia-driven expression of two optical reporters with different half-lives to detect temporal changes in hypoxia and hypoxia inducible factor (HIF) activity. For this purpose, human prostate cancer PC3 cell...

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Bibliographic Details
Published in:Neoplasia
Main Authors: Danhier, Pierre, Krishnamachary, Balaji, Bharti, Santosh, Kakkad, Samata, Mironchik, Yelena, Bhujwalla, Zaver M.
Format: Artigo
Language:Inglês
Published: Neoplasia Press 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4688563/
https://ncbi.nlm.nih.gov/pubmed/26696369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2015.11.007
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